Two simple sensitive and accurate spectrophotometric methods for the determination of pravastatin sodium have been developed and validated. Method A involves oxidative coupling of pravastatin sodium with 3-methyl-2-benzothiazolinone hydrazone (MBTH) in presence of ferric chloride dissolved in HCl and green chromogen is formed and exhibits absorption maxima at 627nm. Method B is an indirect method. This method is based on the bromination of pravastatin sodium by a measured excess of in situ bromine in acid medium followed by the determination of unreacted bromine by reacting with o-dianisidine (ODA) and measuring the absorbance at 440 nm.The final stock solution was made to produce 100�µg/ml and 40�µg/ml with distilled water in method A and method B respectively. The linearity was found in concentration range of 10-50�µg/ml and 2-12�µg/ml for method A and method B respectively. The correlation coefficient was found 0.9991 and 0.9986 for method A and method B respectively. The regression equation was found as y= 0.0175x-0.0015 and y= -0.0x-0.0015for method A and method B respectively. The method was validated according to USP and ICH Guidelines.
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